Functional Promiscuity of Squirrel Monkey Growth Hormone Receptor Toward both Primate and Nonprimate Growth Hormones
نویسندگان
چکیده
منابع مشابه
Functional promiscuity of squirrel monkey growth hormone receptor toward both primate and nonprimate growth hormones.
Primate growth hormone (GH) has evolved rapidly, having undergone approximately 30% amino acid substitutions from the inferred ancestral eutherian sequence. Nevertheless, human growth hormone (hGH) is physiologically effective when administered to nonprimate mammals. In contrast, its functional counterpart, the human growth hormone receptor (hGHR), has evolved species specificity so that it res...
متن کاملBushbaby growth hormone is much more similar to nonprimate growth hormones than to rhesus monkey and human growth hormones.
Unlike other mammals, Old World primates have five growth hormone-like genes that are highly divergent at the amino acid level from the single growth hormone genes found in nonprimates. Additionally, there is a change in the interaction of growth hormone with its receptor in humans such that human growth hormone functions in nonprimates, whereas nonprimate growth hormone is ineffective in human...
متن کاملتأثیر پلی مورفیسم های ژن های هورمون رشد growth hormone و گیرنده ژن هورمون رشد growth hormone receptor روی برخی صفات اقتصادی بز مرغز ایران
در این پژوهش به بررسی وجود پلی مورفیسم در ناحیه پروموتور و اگزون 10 ژن های gh و ghr و ارتباط آنها با صفات رشد در بزهای مرغز پرداخته شد. بدین منظور از سیاهرگ وداج تعداد 160 بز مرغز موجود در ایستگاه اصلاح نژاد استان کردستان خونگیری و dna نمونه ها با استفاده از کیت استخراج گردید. قطعه 391 جفت بازی از ژن gh و 361 جفت بازی از ژن ghr تکثیر شدند. از تفاوت چندشکلی فضایی تک رشته ها (sscp) و توالی یابی ب...
Cognitive correlates of white matter growth and stress hormones in female squirrel monkey adults.
Neurobiological studies of stress and cognitive aging seldom consider white matter despite indications that complex brain processes depend on networks and white matter interconnections. Frontal and temporal lobe white matter volumes increase throughout midlife adulthood in humans, and this aspect of aging is thought to enhance distributed brain functions. Here, we examine spatial learning and m...
متن کاملThe preparation of homogeneous monkey and human pituitary growth hormones.
Simian pituitary growth hormone was prepared in homogeneous form by sequential application of exclusion chromatography on Sephadex G-100, ion exchange chromatography on diethylaminoethyl Sephadex with a single eluent, and density gradient column electrophoresis. DEAESephadex chromatography with a single eluent was also used to separate two biologically active components of human pituitary growt...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2002
ISSN: 1537-1719,0737-4038
DOI: 10.1093/oxfordjournals.molbev.a004166